Gene

otc

ID

ZDB-GENE-070912-422

Name

ornithine transcarbamylase

Symbol

otc Nomenclature History

Previous Names

si:dkey-19h21.3

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable ornithine carbamoyltransferase activity. Predicted to be involved in arginine biosynthetic process via ornithine and citrulline biosynthetic process. Predicted to act upstream of or within amino acid metabolic process. Predicted to be active in mitochondrion. Is expressed in ball; brain; liver; and muscle. Human ortholog(s) of this gene implicated in ornithine carbamoyltransferase deficiency. Orthologous to human OTC (ornithine transcarbamylase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With otc Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
ornithine carbamoyltransferase deficiency	Alliance	Ornithine transcarbamylase deficiency	311250

Associated With otc Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006131	Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
Domain	IPR006132	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
Family	IPR002292	Ornithine/putrescine carbamoyltransferase
Family	IPR006130	Aspartate/ornithine carbamoyltransferase
Homologous_superfamily	IPR036901	Aspartate/ornithine carbamoyltransferase superfamily

Domain Details Per Protein

Protein	Length	Aspartate/ornithine carbamoyltransferase	Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding	Aspartate/ornithine carbamoyltransferase superfamily	Ornithine/putrescine carbamoyltransferase
UniProtKB:E9QHD9 InterPro	352

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	otc-201 (1) Ensembl	Ensembl		1,239 nt	Select Tool ZFIN BLAST
ncRNA	otc-002 (1) Ensembl	Ensembl		753 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations